Matrixyl, also known as Palmitoyl Pentapetide 3 (and later renamed to Palmitoyl Pentapeptide 4 or Pal-KTTKS), is a small molecule made up of 5 amino acids linked to a fatty acid. The fatty acid component helps to increase its penetration into the skin.

Matixyl's main use in skin care preparations is as an alternative to retinoids in wrinkle treatments. Matrixyl tends to better tolerated than retinoids which are known to cause irritation in some individuals. Studies on skin cells have shown that Matrixyl helps to boost the production of collagen, elastin and glycosaminoglycans, the key constituents of the skin's matrix.

Though Matrixyl doesn’t have as many clinical studies as Vitamin C or retinoids to back up its claims, there is data to support its being as effective as retinol in reversing the effects of sun damage as well as improving the appearance of wrinkles. And, it tends to be well tolerated, with few side effects being reported.

Should You Add Matrixyl to Your Skin Care Routine?

If you can’t tolerate retinoids, (many individuals just find them too irritating), or if you wish to try a product that works via a different pathway to achieve synergistic (additive) effects, then a Matrixyl preparation may be right for you. If this is the case look for one containing at least 3% Matrixyl, which was the minimum effective concentration used in the clinical studies.

You may want to consider [Link Removed] Formulated with 5% Matrixyl, studies have shown it to improve the appearance of wrinkles and it is well tolerated.

Sharmani Pillay is a Registered Pharmacist who specializes in anti aging skin care. She owns and operates an online skin care store at [Link Removed] 

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